When using Outlook templates and MS Exchange Server accounts, whichever profile you open last with ExtraOutlook becomes the default sending account. When you open your Outlook template (in my case from the toolbar), it will switch to the last instance of Outlook and use that accounts profile as the From address. If you change the From address to another Exchange Server account and it is not specified as a delegate of the last profile you opened, you won’t be able to send the e-mail. You have to close all Outlook instances (except the profile you want to send from), create the e-mail in that profiles Outlook instance, and then send it. And since you can’t have more than one Exchange Server account in your e-mail addresses, you can’t save the template with a pre-selected account, because it only sees the default account.